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Taken from WWW.pubmed.gov (testosterone studies)
Circulation. 2007 Nov 26 [Epub ahead of print]
Endogenous Testosterone and Mortality Due to All Causes, Cardiovascular Disease, and Cancer
in Men. European Prospective Investigation Into Cancer in Norfolk (EPIC-Norfolk) Prospective Population
Study.
Khaw KT, Dowsett M, Folkerd E, Bingham S, Wareham N, Luben R, Welch A, Day N.
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge
School of Clinical Medicine, Cambridge, UK; Academic Department of Biochemistry, Royal Marsden Hospital,
London, UK; and MRC Dunn Human Nutrition Unit and MRC Epidemiology Unit, Cambridge, UK.
Background: -The relation between endogenous testosterone concentrations and health in men is
controversial.
Methods and Results-We examined the prospective relationship between endogenous
testosterone concentrations and mortality due to all causes, cardiovascular disease, and cancer in a
nested case-control study based on 11 606 men aged 40 to 79 years surveyed in 1993 to 1997 and followed
up to 2003. Among those without prevalent cancer or cardiovascular disease, 825 men who subsequently died
were compared with a control group of 1489 men still alive, matched for age and date of baseline visit.
Endogenous testosterone concentrations at baseline were inversely related to mortality due to all causes
(825 deaths), cardiovascular disease (369 deaths), and cancer (304 deaths). Odds ratios (95% confidence
intervals) for mortality for increasing quartiles of endogenous testosterone compared with the lowest
quartile were 0.75 (0.55 to 1.00), 0.62 (0.45 to 0.84), and 0.59 (0.42 to 0.85), respectively
(P<0.001 for trend after adjustment for age, date of visit, body mass index, systolic blood pressure,
blood cholesterol, cigarette smoking, diabetes mellitus, alcohol intake, physical activity, social class,
education, dehydroepiandrosterone sulfate, androstanediol glucuronide, and sex hormone binding globulin).
An increase of 6 nmol/L serum testosterone ( approximately 1 SD) was associated with a 0.81 (95%
confidence interval 0.71 to 0.92, P<0.01) multivariable-adjusted odds ratio for mortality. Inverse
relationships were also observed for deaths due to cardiovascular causes and cancer and after the
exclusion of deaths that occurred in the first 2 years.
Conclusions-In men, endogenous testosterone concentrations are inversely related to mortality due to
cardiovascular disease and all causes. Low testosterone may be a predictive marker for those at high
risk of cardiovascular disease.
PMID: 18040028 [PubMed - as supplied by publisher]
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