Testosterone Deficiency The Hidden Disease
by E. Barry Gordon, M.D.
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Taken from WWW.pubmed.gov (testosterone studies)
Can J Urol. 2006 Feb;13 Suppl 1:46-7.
Inflammation and prostate cancer.
Sugar LM.
There is emerging evidence that prostate inflammation may contribute to prostatic carcinogenesis. Chronic inflammation
has been associated with the development of malignancy in several other organs such as esophagus, stomach, colon, liver and
urinary bladder. Inflammation is thought to incite carcinogenesis by causing cell and genome damage, promoting cellular turnover, and creating
a tissue microenvironment that can enhance cell replication, angiogenesis and tissue repair. Epidemiological data have correlated prostatitis and sexually
transmitted diseases with an increased risk of prostate cancer and intake of anti-inflammatory drugs and antioxidants with a decreased risk. Evidence
from genetic and molecular studies also support the hypothesis that prostate inflammation and/or infection may be a cause of prostate cancer. In 1999
De Marzo et al proposed that proliferative inflammatory atrophy (PIA) is a precursor to PIN and cancer. Further research will provide opportunities
for the discovery and development of strategies for treatment and prevention of prostate cancer.
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