Testosterone Deficiency The Hidden Disease
by E. Barry Gordon, M.D.
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Taken from WWW.pubmed.gov (testosterone studies)
Carcinogenesis. 2005 Jul;26(7):1170-81. Epub 2004 Oct 21.
Prostate carcinogenesis and inflammation: emerging insights.
Palapattu GS, Sutcliffe S, Bastian PJ, Platz EA,
De Marzo AM, Isaacs WB, Nelson WG.
Prostate cancer remains a significant health concern for men throughout the world.
Recently, there has developed an expanding multidisciplinary body of literature suggesting
a link between chronic inflammation and prostate cancer. In support of this hypothesis, population
studies have found an increased relative risk of prostate cancer in men with a prior history of
certain sexually transmitted infections or prostatitis. Furthermore, genetic epidemiological
data have implicated germline variants of several genes associated with the immunological aspects
of inflammation in modulating prostate cancer risk. The molecular pathogenesis of prostate cancer
has been characterized by somatic alterations of genes involved in defenses against inflammatory
damage and in tissue recovery. A novel putative prostate cancer precursor lesion, proliferative
inflammatory atrophy, which shares some molecular traits with prostate intraepithelial neoplasia
and prostate cancer, has been characterized. Here, we review the evidence associating chronic
inflammation and prostate cancer and consider a number of animal models of prostate inflammation
that should allow the elucidation of the mechanisms by which prostatic inflammation could lead
to the initiation and progression of prostate cancer. These emerging insights into chronic
inflammation in the etiology of prostate carcinogenesis hold the promise of spawning new diagnostic
and therapeutic modalities for men with prostate cancer.
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